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Revolutionizing CAR-T Therapy: The CTLA-4 Tail Fusion Advantage
Chimeric antigen receptor (CAR)-T cells, although potent therapeutics, often face significant challenges in achieving their full efficacy. In this study, it is stated that the endocytic capability of the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) cytoplasmic tail to revamp CAR functionality and significantly bolsters CAR-T cell effectiveness in live subjects. The molecular dynamics of reengineered CAR with […]
How a Drug That Blocks a Brain Chemical Can Help Mice Lose Weight
Promising Phase 1 clinical trials reveal a groundbreaking drug that effectively reduced weight and fat mass in obese mice without affecting their appetite. The drug targets astrocytes, brain cells responsible for regulating body weight by influencing specific neurons. Researchers found that astrocytes release an inhibitory neurotransmitter called GABA, which hampers the activity of GABRA5 […]
The Learning ability of the Brain Could be Influenced by Caffeine
Getting through a serious amount of caffeine each day could put the brakes on the brain’s ability to rewire itself. Researchers analyzed brain signals associated with learning and lodging memories in 20 individuals, uncovering surprising details and challenging assumptions that caffeine promotes plasticity. Chronic caffeine use could limit learning Thanks to its ability to block […]