The Future of Fake News Detection: Machine Learning and Blockchain
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Off the track:Athlete fertility problems on the rise
In recent years, a concerning trend has emerged within the athletic community, shedding light on the increasing incidence of reproductive problems among athletes. While these individuals are celebrated for their physical prowess and dedication to their respective sports, the off-field challenges they face in terms of reproductive health remain largely overlooked. Body: Athletes, despite their […]
Battling Hospital-Acquired Pneumonia Reveals Strategies for Tackling Antibiotic Resistance
Hospital-acquired pneumonia (HAP), often caused by Pseudomonas aeruginosa, poses a significant health threat. Meropenem, a common therapeutic agent, faces emergent resistance during treatment. Using a rabbit HAP model, we assessed meropenem’s pharmacodynamics. Dose-response and emergent resistance displayed an inverted U relationship. Combining amikacin with meropenem suppressed resistance. Mechanisms included porin loss, efflux upregulation, and increased […]
Revolutionizing CAR-T Therapy: The CTLA-4 Tail Fusion Advantage
Chimeric antigen receptor (CAR)-T cells, although potent therapeutics, often face significant challenges in achieving their full efficacy. In this study, it is stated that the endocytic capability of the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) cytoplasmic tail to revamp CAR functionality and significantly bolsters CAR-T cell effectiveness in live subjects. The molecular dynamics of reengineered CAR with […]